Validation of techniques for the destruction of dimethyl. Show this safety data sheet to the doctor in attendance. Theoretical study of the thermal decomposition of dimethyl. It may also be used in combination with dimethylformamide dmf to form methoxymethylenen, ndimethyliminium salt, that can.
Despite its use in a wide variety of industrially important thermochemical processes, little is known about the thermal decomposition mechanism of dimethyl disulfide dmds. It has been reported that dimethyl sulfate dms can be degraded with sodium hydroxide solution 1 moll, sodium carbonate solution 1 moll, or ammonium hydroxide solution 1. This compound is the monomethyl ester of sulfuric acid. Dimethyl sulfate ch3o2so2 or c2h6o4s cid 6497 structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safetyhazardstoxicity information, supplier lists, and more. While there are a few methods to determine the genotoxic compound dms, the determination of mms has. Dimethyl sulfate dms, a common reagent for chemical probing in singlestranded rna regions, methylates adenine at n1, guanine at n7, and cytosine at n3, but only the adenine and cytosine methylations inhibit the progress of reverse transcriptase while methylation of guanine at n7 may be detected by treatment with sodium borohydride and. Dimethyl sulfate and other diesters of sulfuric acid are powerful alkylating agents, widely used in organic synthesis and chemically induced mutagenesis. Decomposition no data available temperature r viscosity no data available s explosive properties no data available. This may last for up to 72 hours after you get dimethyl sulfoxide.
Analytical methods dimethyl sulfate dms is a very slightly odorous, oily liquid. Diethyl sulfate mak value documentation, 2003 major. Dimethyl sulphate included in the candidate list of substances of very high concern svhc according to regulation ec no. Determination of low ppm levels of dimethyl sulfate in an. Inhalation exposure to dimethyl sulfate results in irritation and other adverse effects.
Thermal decomposition may release sulfur dioxide at extremely high temperatures. This material does not contain any class 1 ozone depletors. To view publication numbers, click the show publication numbers link at the top of the list. Dimethyl sulfate is a chemical compound with formula ch3o2so2. Its use continues to be widespread despite it being highly toxic and a probable carcinogen. Accidental release measures personal precautions use personal protective equipment as required. The only advantage to dimethyl sulfate over methyl iodide that i can is that it is cheaper and more suitable for industrial manufacturing. Its physical and chemical properties are largely like those of the lower homologue dimethyl sulfate see documentation in volume 4 of the present series but its acute toxic and cytotoxic effects are less severe couch et al. Dimethyl sulfate is a suspect carcinogen, and both the liquid and vapor are extremely severe irritants to skin, eyes, and mucous membranes. It has a role as an alkylating agent and an immunosuppressive agent. Dimethyl sulfone is an oxidation product of dimethyl sulfoxide dmso and provides a source of sulfur, used for the creation of two amino acids methionine and cysteine.
Safety data sheet spent acid sinclair oil corporation. The following is a complete list of all publications issued by niosh. Dimethyl sulfate dms and monomethyl sulfate mms are potential genotoxic impurities created during synthesis of some active pharmaceutical ingredients. Empirical degradation data for dimethyl sulfate are presented in table 4.
N,n,ntrimethyl chitosan tmc is one chitosan derivative that, because of its improved solubility, has been studied for industrial and pharmaceutic applications. Dimethyl sulfate revision date 25jan2019 component casno weight % dimethyl sulfate 77781 95 4. Dimethyl sulfate dmso4, table 1 has been used since the beginning of the 20th century as a methylating agent in industrial chemical synthesis. First aid measures general advice consult a physician. Us1401693a us26323918a us1401693a us 1401693 a us1401693 a us 1401693a us 26323918 a us26323918 a us 26323918a us 1401693 a us1401693 a us 1401693a authority us united states prior art keywords dimethyl sulfate dimethyl sulfate sulfur preparation prior art date 19181119 legal status the legal status is an assumption and is not a legal conclusion. Dimethyl sulfate enters air and water largely through various waste streams resulting from its production and use. Personal protective equipment should be used to prevent any bodily exposure even to the vapor. Methyl bisulfate is a chemical compound with the molecular formula ch 4 o 4 s. Dimethyl sulfate is a chemical compound with formula ch 3 o 2 so 2. Dimethyl sulfate is miscible with organic solvents, and moderately soluble in water.
So find msds or sds, a coa, data sheets and more information. Dimethyl sulfate ignites in contact with unheated barium chlorite, due to the rapid formation of unstable methyl chlorite. Dimethyl sulfate is the dimethyl ester of sulfuric acid. Sial dimethyl sulfate, sial dimethyl sulfate, sial dimethyl sulfate, dimethyl sulfate 1ml, dimethyl sulfate, 99. Dimethyl sulfate is a colorless, oily liquid with a faint onion like odor. Dimethyl sulfate final version echa european union.
Me 2 so 4 is mainly used as a methylating agent in organic synthesis me 2 so 4 is a colourless oily liquid with a slight onionlike odour although smelling it would represent significant. It may also be used in combination with dimethylformamide dmf to form methoxymethylenen,ndimethyliminium salt, that can be utilized for the preparation of. Colorless oillike inflammable liquid boiling point 188. Dimethyl sulfate ch3o2so2 or c2h6o4s cid 6497 structure, chemical names, physical and. Dimethyl sulfate may be used along with alumina for preparation of monomethylated derivatives of alcohols, phenols and carboxylic acids. As the diester of methanol and sulfuric acid, its formula is often written as ch 3 2 so 4 or even me 2 so 4, where ch 3 or me is methyl. Sheet msds and the label to determine product ingredients and. Slowly reacts with water to form ethyl alcohol, a flammable liquid, and ethyl sulfate, with eventual conversion to sulfuric acid. These are not all of the side effects that may occur.
Covid19 is an emerging, rapidly evolving situation. The routes of potential exposure to dimethyl sulfate are inhalation, dermal contact, and ingestion hsdb 2009. Monoalkyl sulfates, in contrast, undergo spontaneous hydrolysis only at high temperatures and appear never to have been shown to act as alkylating agents under any conditions. N,n dimethyl pphenylenediamine sulfate revision date 19jan2018 hazardous decomposition products nitrogen oxides nox, carbon monoxide co, carbon dioxide co 2, sulfur oxides hazardous polymerization no information available. Dimethyl sulfate blue silica gel hydroxylamine hydrochloride. Thermal decomposition can lead to release of irritating gases and vapors. Firstaid measures general advice show this safety data sheet to the doctor in attendance. Dimethyl sulphate material safety data sheet cas no 7778. Sulfides result from the decomposition of organic matter, from bacterial sulfate reduction under anaerobic conditions and from various chemical processes. Based on these data, the estimated volumetric capacity decreases from 39 l at 25 c to 16 l at 35 c. This involved a sulfur ester such as dimethyl sulfate, mca case history no.
Just when i thought my entire book collection contained only a single paragraph on dimethyl sulphate telling me how great it is for methylations due to its high boiling point, fownes turns up a prep for methyl hydrogen sulphate above, similar to the rhodium one, and a surprisingly simple prep for dimethyl sulphate. The gradual decomposition renders the melting point of limited value and dependent on the rate of heating, although it is sharply defined. However, in the lab, it is still much more preferred than dimethyl sulfate. Determination of genotoxic impurities monomethyl sulfate. Preparation of n, n, ntrimethyl chitosan via a novel. Skin odor and breath odor like a garliclike taste has happened with dimethyl sulfoxide. Rapporteur for the risk evaluation of dimethyl sulphate is the ministry of housing. Highly toxic fumes contaning sulfur oxides may be generated along with thermal decomposition products such as ethyl ether and ethylene. Safety data sheet spent acid section 1 identification product name. It is an insidious hazard warning properties are poor and symptoms are delayed up to 10 h or more 3,4. Article views are the countercompliant sum of full text article downloads since november 2008 both pdf and html across all institutions and individuals. If youre talking about toxicity, its worth noting that methyl iodide is also a vesicant, carcinogen, and a poison. Conventional methods for the synthesis of tmc involve the use of highly toxic and harmful reagents, such as methyl iodide and dimethyl sulfate dms. It should be noted that the use of the classic electrophilic reagents comes with a high risk of toxicity.
Dimethyl sulfate 2524 wikisource, the free online library. Fire hazard special hazards of combustion products. The significance of methyl bisulfate is that it is an intermediate in the hydrolysis of the important reagent dimethyl sulfate, ch 3 2 so 4. Dimethylsulfate is formed and consumed in a complex set of interrelated equilibria. The initial sets of experiments were designed to inves tigate the formation k1 and degradation k. To obtain more insight, the radical decomposition mechanism of dmds is studied theoretically and a kinetic model is developed accounting for the formation of all the decomposition products observed in the experimental. Dimethyl sulfate is a colorless, oily liquid that is slightly soluble in water. Unfortunately, methyl iodide is expensive and has a high acute toxicity for inhalation and ingestion, and dimethyl sulfate, although it is lowpriced, is carcinogenic and environmentally hazardous. At last,dimethyl sulfate77781 safety, risk, hazard and msds, cas,cas number,use,cas no may. Dimethyl sulfate is used as a methylating agent in the manufacture of many organic chemicals. It is also used in the manufacture of dyes and perfumes, for the separation of mineral oils, and for the analysis of auto fluids. All transfers involving dimethyl sulfate should be performed in a fume hood. Dimethyl sulfate may be decomposed by adding a dilute alkaline solution. According to epas toxics release inventory, environmental releases of dimethyl sulfate from 1988 to 2002 ranged.
In supplement form, dimethyl sulfone is an odorless, white, crystalline and watersoluble compound. Determination of low ppm levels of dimethyl sulfate in an aqueous soluble api intermediate using liquidliquid extraction and gcms. At last,dimethyl sulfate77781 safety, risk, hazard and msds, cas,cas number,use,cas no may also be you need. Dimethyl sulfate is a colorless oily liquid, odorless to a faint onionlike odor.
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